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PostPosted: Fri Feb 17, 2017 2:18 pm 
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Intravenous protocols using Colloidal Silver were fairly commonly employed during the first half of the 20th century. Here are some excerpts from old medical journals:


Intravenous Injections of Colloidal Silver.—Francke (Medizinische Klinik, 1908, iv, 12)

Quote:
. . .states that in grave infectious processes, such as sepsis, puerperal and otherwise, colloidal silver should be employed in 4 to 5 per cent, solution as an intravenous injection, 30 grains being injected daily or every other day, according to the type of the affection and the effect of the remedy. In one instance of severe gonorrhceal sepsis, with chills persisting for weeks, one such injection brought about a rapid and permanent fall of temperature. Injections of colloidal silver are usually followed by a chill succeeded by a rise of temperature even as high as 105.8° F., but this phenomenon has no untoward sequels. The employment of this agent by intravenous injection is superior to its exhibition by enema or inunction, and the former is the preferable mode of administration.


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Intravenous injections. Rabbits inoculated with fatal dose of staphylococcus aureus did not die if 1 cubic centimeter of a 1 per cent colloidal silver chloride solution was given intravenously 15 to 20 hours later. The control rabbits which received similar injections and not treated with colloidal silver chloride promptly died with multiple abscesses of the kidneys, heart, and other organs.

The rabbits were sometimes not disturbed by 2 cubic centimeters of the same solution given intravenously. Freshly made solutions were found to have greater germicidal value than the preparations several days or a week old.


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Quote:
COLLOIDAL SILVER BY RECTUM

Dr. H. S. Loebl, of the Franz Joseph Hospital, reports that during the past two years unguentum Crede and collargol have been used very frequently in Dr. Schlesinger's wards. In some cases intravenous injections of collargol (colloidal silver) were found impossible on account of obesity or smallness of the veins. Collargol cnemata of 2\ to 4} grn. in z\ oz. of distilled water were then administered twice daily for eight days, a cleansing enema being given beforehand. Besides the histories of two cases, the speaker demonstrated the temperature curves of three severe cases of sepsis, a puerperal infection, and a thrombo-phlebitis following typhoid, in which the favorable results were doubtless due to collargol. In four cases the enemata had to be stopped, partly because of negative results, partly on account of other complications. No definite results were obtained in six feverish phthisical cases. The advantages of the enemata lie in their safety and simplicity, and in the ease with which the dosage may be increased.

Prof. Hermann Schlesinger also believes that collargol (a colloidal silver formulation) is a most effective weapon in septic conditions. Especially when administered intravenously, Schlesinger has seen apparently hopeless cases saved by it. In his experience the rectal application was just as effective as the intravenous method. —Wien. klin. Woch., 1903, No. 44.





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SOME FURTHER EXPERIENCES
WITH SOLUBLE SILVER.


BY A. DWORETZK.Y, M. D.,
OF RIGA.


Quote:
The author first draws attention to the difficulty of judging the effects of therapeutic procedures, and to the necessity of prolonged observation of the natural course of the diseases in which they are employed as well as extensive experimentation before deciding as to their efficacy. Nothing is more hurtful than premature conclusions and the false expectations which they necessarily entail. His results show, however, that the medication under consideration simplifies the treatment of affections which is otherwise difficult, tedious and complicated; that it hastens their frequently uncertain and lengthy cure; and that it shows a specific action entirely different from that of other preparations and methods. His paper is designed to furnish further statistical data on the question of internal blood disinfection by means of colloidal silver, the soluble antimycotic chemical introduced by Crede in the year 1897.

After referring to the extensive literature of the drug, and to the seven cases of erysipeloid and septic abscess with general infection, furunculosis, osteomyelitis, and puerperal fever treated with excellent results with the unguentum Crede which he has himself reported (Zeitschrift fur praktische Aerzte, No. 17, 1898, Therapeutische Monatshefte, No. 23, 1900,) he states that he has ten further cases in which treatment with the soluble silver (collargolum) was most satisfactory in its effect.

Comparative therapeutics, though but little studied, is undoubtedly of greater value in determining the properties of a remedy than laboratory experiments made upon healthy animals; and Uworetzky lays stress upon the results obtained by Dieckerhoff in the treatment of the morbus maculosus of horses; to which we have already referred. P. Meissner (Berliner thierarztliehe Wochenschrift No. 11, 1899), Lemhofer (Berliner thierarztliche Wochenschrift, No. 11, 1899), Kroning (Zeitschrift fur Veterinarkunde, No. 3, 1899), Richter (Zeitschriftfur Veterinarkunde, No. 6, 1899),Loef (Zeitschrift fur Veterinarkunde, No. 6, 1899), and Roder (Archiv fur unssenschaftliche und praktische Thierheilkunde, Nos. 3 and 4, Vol. xxv), have confirmed the report of its prompt action in this affection, in which veterinary medicine is otherwise powerless.

A. Weidmann (Oestreichische Monatsschrift fur Thierheilkunde, etc., No. 12, 1897 and No. 8, 1898) has employed the remedy in lymphangitis, phlegmons and various septic diseases in animals, and has noted especially favorable effects on the general condition. He rapidly and permanently cured obstinate otitis in dogs by the local use of lactate of silver (actol) solutions and the unguentum Crede.

Intravenous injection of the collargolum ( a CS product) has been successfully employed by Tannebring (Berliner Thierarztliche Wochenschrift, No. 14,1899) and Meissner (ibid) in the malignant, catarrhal fever of the cow, an affection otherwise usually fatal; by Krtiger, (Berliner thierarztliche Wochenschrift, No. 14, 1899) in a severe and otherwise hopeless case of intestinal anthrax in the cow. C. Evers (Berliner thierarztliche Wochenschrift, No. 15, 1900), found it a very efficacious prophylactic measure for the dysentaria neonatorum of calves, which is caused by a micro-organism, is highly contagious, and increases in virulence in its transmission from animal to animal. In two hundred and fifty cases he gave the calves repeated intravenous injections during the first three days of extrauterine life with excellent results; and his methods were beyond cavil, and his findings supported by numerous controll experiments. Briihlmeyer (Zeitschrift fur Veterinarkunde, No. 3, 1899) indeed got no effect from the repeated intravenous injection of colloidal silver in a very advanced case of phlegmon of the glutei in a horse; but Professor Roder (Archiv furwisscnschaftlicheund praktische Thierhcilkunde, Nos. 3 and 4, Vol. xxv), cured a similar case by a single energetic inunction of the colloidal silver ointment.

Tetzner (Zeitschrift fur Veterinarkunde, etc., Nos. 8 and 9, 1899) finds the dessicating action of the colloidal silver especially noticeable in obstinate ulcerations with unhealthy, readily bleeding granulations. A chronic lymphangitis with tendency to abscess formation in ahorse was entirely cured by the injection of 1 gram (15 grains) of collargolum, repeated after two days.

The fact that horses suffering from chronic and concealed glanders have their symptoms increased by the intravenous silver injections, so that the affection becomes acute and can be readily diagnosticated, is of the greatest interest.

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Quote:
Colloidal silver was first described by Carey Lea in the American Journal of Sciences in 1889; but- his discovery was simply a laboratory curiosity without practical value, as his product was unstable and impure and had no field of application. Crede of Dresden, working wholly independently (Lea's experiments were found by him only in later researches), came to the conviction that an efficient general body disinfection could be accomplished only by metallic but soluble silver, and not by means of silver salts; and he instructed the Heyden chemical factory to make experiments in this direction. It is due to his work as well as to that of the Heyden factory, that, by new and improved processes, a stable and pure colloidal silver (collargolum) was elaborated. And it was Crede who developed the method of internal silver treatment.

Collargolum consists of small, hard, brittle, bluish-black scale-like pieces. It is soluble in distilled water to the extent of 1:20 and remains stable even after months. Solutions may be prepared with ordinary drinking water. They may be boiled, but this is unnecessary, as collargolum is itself antiseptic. Lea's colloidal silver precipitates on being boiled.

Collargolum may be introduced into the organism by inunction, subcutaneously, by mouth, rectally and intravenously. When given by inunction, absorption takes place in the upper layers of the corium. The dose of collargolum ointment (unguentum Cred6) is 1 to 3 grams given 1 to 4 times daily. In chronic sepses (furunculosis, puerperal fever) up to 30 inunctions may be given.

The effects of the subcutaneous injection are less rapid and certain, absorption being slow. Per os, 1:1000 to 1:200 collargolum solutions may be given in teapoonful or tablespoonful doses 2 to 5 times daily on an empty stomach; this is especially indicated in dysentery, gastric catarrhs, etc. As an enema, 1:500 solutions are used, a cleansing clyster being given beforehand. This should be given twice daily for at least 8 days. The method is praised by Prof. Schlesinger and Drs. Loebl and Kornfeld for its simplicity and safety, and because larger doses can be conveniently administered. The action of the silver when introduced by this route is especially energetic on the neighboring organs, such as the uterus and peritoneum. But the best method is the intravenous, which is perfectly safe and is especially indicated when the blood is the seat of infection, as in endocarditis.

As collargolum is rapidly eliminated, it must be constantly supplied to the organism when a permanent effect is desired. Its efficacy is fully apparent onjy when the whole clinical picture, not merely temperature and pulse, is considered. In a septic process the temperature does not always correspond to the severity of the infection; and equal importance must be conceded to the general symptoms. After the use of collargolum subjective improvement almost invariably precedes temperature or pulse improvement, occurring, when given intravenously, after 4 to 6 hours, and when inuncted after 8 to 12 hours. Nervousness, headache and stupefaction abate, the patient is relieved and refreshed, and shows more interest in his surroundings. Appetite and sleep return. Often there is a mild diaphoresis and increased intestinal activity. Collargolum directly combats the septic affection and inhibits bacterial development.

But the antiseptic has of course its limitations. It may fail to save moribund patients or those in whom the powers of heart and the vasomotors are exhausted. Nor can it affect abscesses which are out of the reach of the body fluids. Its use should be begun as soon as there is danger of the spread of a local infection.

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PostPosted: Fri Feb 17, 2017 2:20 pm 
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Colloidal Silver injectable cannot be purchased on the open market, If I were interested in making an injectable form, one could probably make one's own Colloidal silver injectable from start. If so, I would start with sterile injectable USP water, put this in a CS generator to get around 10ppm, then filter through a .2 micron sterile filter into an appropriate sterile vial. One would need to follow as aseptic conditions as possible throughout.

Check out my web:

http://racehorseherbal.net/inj%20CS.html

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PostPosted: Fri Feb 17, 2017 2:22 pm 
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It is written in many places on the internet that the addition of Hydrogen peroxide to Colloidal Silver is recommended to improve antimicrobial action. This is pretty much claimed because of research done by Rami Pedahzur, Ovadia Lev, Badri Fattal and Hillel I. Shuval in their study entitiled: The interaction of silver ions and hydrogen peroxide in the inactivation of E. coli: a preliminary evaluation of a new long acting residual drinking water disinfectant from Water Science and Technology Vol 31 No 5-6 pp 123–129 © IWA Publishing 1995 :


Quote:
ABSTRACT
The inactivation efficiencies of silver ions, hydrogen peroxide and their combination was studied as part of a performance evaluation of the combined disinfectant for drinking water applications. The major advantages of such combined disinfectant include, low toxicity of its components, long lasting residual effect and low disinfection by product formation. Specific strains of E. coli (E. coli-B (SR-9) and E. coli K-12) were used in this study as target microorganisms and the separate and combined inactivation efficiencies of silver and hydrogen peroxide were evaluated at different concentrations and exposure durations. Both, silver and hydrogen peroxide exhibited a significant inactivation performance even at concentrations that do not pose any health risk according to the EEC, WHO and the USEPA (the USEPA Maximum Contaminant Level (MCL) of silver is 90 ppb, and currently, there is no MCL for hydrogen peroxide but it is approved as a food additive in the USA). Combinations of 1:1000 silver:hydrogen peroxide (w) exhibited higher inactivation performance as compared with each of the disinfectants alone and in some cases a synergistic effect was observed, i.e., the combined disinfectant exhibited higher inactivation performance than the sum of the inactivation levels of the separate disinfectants. Thus, for example, one hour exposure to 30 ppb silver, 30 ppm hydrogen peroxide and their combination yielded 2.87, 0.65 and 5 logs of inactivation respectively. While the rate of inactivation shown by this combined disinfectant, now available commercially in a stabilized formulation is relatively slow, it may well hold promise as a secondary disinfectant providing long lasting residuals and biofilm control required for distribution systems. Its disinfection action may be similar to chloramines, the use of which has been recently outlawed in France and in Germany and which are now under careful scrutiny in other countries due to the formation of undesirable by-products.




How this data would translate to a injectable formulation is debatable but worth consideration

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Here is an interesting US Patent application of Colloidal Silver and Hydrogen Peroxide:

Quote:
Generally, the present invention represents a novel approach to killing or disabling microorganisms which are hazardous to human beings by the use of silver particles in water, at a concentration of 5 to 40 ppm silver. Depending upon the application, the silver composition may be used internally or externally. Depending on the application, the silver composition may also contain hydrogen peroxide.

A composition comprising silver particles, colloidally suspended in water, wherein the total content of silver is between 5 and 40 ppm, which composition kills or disables microorganisms which are hazardous to the human body.

A further class of embodiments is the combination of any of the above-described embodiments with hydrogen peroxide, at a level of 1 -3 wgt % hydrogen peroxide in the final product.

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