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PostPosted: Fri Jun 26, 2015 12:44 pm 
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I just obtained a copy of Dr. David Williams' book, "DMSO, The Complete Up-to-Date Guidebook' (1993). In it I found interesting that he said the only difference between industrial grade DMSO and pharma grade was this:

Quote:
"Basically, prescription DMSO goes through two procedures that "over-the-counter" DMSO doesn't.

1) it is sterilized by filtration.
2) it is pyrogen tested.

To sterilize DMSO, the product is passed through a very fine filter that removes any particles the size of bacteria and larger. Most researchers, clinicians and medical professionals consulted, questioned the need for sterilization. If you remember DMSO is bacteriostatic at concentrations of 35% or above; at these concentrations, it stops bacteria growth.

Pyrogen testing is a costly and time consuming procedure. A pyrogen is any substance that causes a fever. To test a batch of DMSO for pyrogens, laboratory animals treated with the drug and then their temperatures are monitored on a regular basis. This procedure is felt by many to be another instance of FDA "overkill". Most informed authorities agree that pyrogen testing is definitely not necessary for DMSO intended for topical use. Many even question its necessity for DMSO used to treat interstitial cystitis by catheter."




I say to this, if this is true, one can easily filter over-the-counter DMSO with .22 micron filter set-ups and save hundreds of dollars. When choosing a filter material to filtrate DMSO, it is good to know this:

DMSO is incompatible with polysulfone, flexible and rigid PVC tubing and polycarbonate.

It is moderately compatible with polystyrene and ECTFE/ETFE.

It is compatible with LDPE, HDPE, polypropylene, PPCO polypropylene copolymer polymethylpentene,
nylon and teflon FEP.

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PostPosted: Fri Jun 26, 2015 12:46 pm 
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I also want to clarify here the chemical grades used and purity issues involved as so many of us would prefer to have DMSO in pharmaceutical grade or as is commonly labeled, USP. This is particularly true if we want DMSO for something more than just topical use, such as IV applications.

Below are the common grades:

1. A.C.S.
A chemical grade of highest purity and meets or exceeds purity standards set by American Chemical Society (ACS).

2. Reagent
High purity generally equal to A.C.S. grade and suitable for use in many laboratory and analytical applications.

3. U.S.P.
A chemical grade of sufficient purity to meet or exceed requirements of the United States Pharmacopeia (USP); acceptable for food, drug, or medicinal use; may be used for most laboratory purposes.

4. N.F.
A grade of sufficient purity to meet or exceed requirements of the United States National Formulary. (Since bought out and merged with the United States Pharmacopeia, USP-NF.)

5. Lab
A chemical grade of relatively high quality with exact levels of impurities unknown; usually pure enough for educational applications. Not pure enough to be offered for food, drug, or medicinal use of any kind.

6. Purified
Also called pure or practical grade, and indicates good quality chemicals meeting no official standard; can be used in most cases for educational applications. Not pure enough to be offered for food, drug, or medicinal use of any kind.

7. Technical (industrial)
Good quality chemical grade used for commercial and industrial purposes. Not pure enough to be offered for food, drug, or medicinal use of any kind.


NOTE: The highest purity level of chemicals is the ACS grade. It is even higher than the much coveted USP grade! So if you want to cut costs, avoid the expense of a prescription from a MD or DVM, then simply look for DMSO in ACS grade!

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