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 Post subject: Oleander extract
PostPosted: Mon Jun 27, 2016 10:02 am 
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From the US Patent on making Oleander extract:


Quote:
Example 1

Preparation of Nerium oleander L. Extract

Add about 10 g of air dried, sliced into pieces leaves, branches and flowers of Nerium oleander to 100 ml of distilled water in 200 ml of round-bottom flask, heat it up to 100° C. and keep boiling for 3 h.

During boiling, add distilled water to maintain a constant water level.

After boiling, bring the temperature of the mixture to 20-25° C., filter using a coarse filter in order to separate from plant material and remove from particulate matters.

Bring filtrate to the volume of 100 ml with distilled water and subject it to sterile filtration into sterile flask using Millipore filters with pore size 0.45 μM and 0.22 μM consequently.

Store solution at 4° C. for one year.








From: https://www.google.com/patents/US20060188585

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 Post subject: Re: Oleander extract
PostPosted: Mon Jun 27, 2016 10:05 am 
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Oleander soup recipe:


Quote:
Wear rubber gloves and use garden hand trimmers to trim oleander new growth stems and leaves 6" from tip. Any part of the plant can be used, but trimming the new growth 6 to 8 inches from the tips will ensure that the plant lives. Six inches is best, because that easily fits into the boiling pot. If you use a larger or a smaller pot, cut the length of the leaves an inch less than the diameter of the pot.

Put the cuttings in a plastic shopping bag. Avoid touching cut ends, use gloves, as the sap will penetrate skin and is toxic.

Use a large porcelain or stainless steel steam pot, up to 12 quarts in size, into which you stuff the trimmings to 2" from top. This is the same kind of pot used for making jellies and canning. Fill with water to the top of the trimmings. Pack the oleander down into the water and put the pot lid on, making sure the water level is at least two inches from the top, so it won`t boil over.

Boil at a slow, rolling boil, steaming, with the lid on for 3.5 to 4 hours.

Remove plant material with tongs and discard carefully, using tongs or a screen ladle. Be careful not to spill the liquid on you, it is hot.

Volume remaining should be about 60 to 70% of the original liquid.

Boil this slowly again for about 2 to 3 hours, reducing the liquid again by 50%, to about 30% of original liquid. Let this cool to room temperature, sitting covered for about two hours. This liquid should be as thick as chicken soup broth, pouring easily into a straining pot.

Strain the remainder through 4 layers of paper towels using plastic colanders, which are commonly available in grocery stores, the plastic 99 cent ones work great. Stack one on top of another with a towel in between each. The top towel may plug and need to be replaced. Use a soup ladle to slowly pour the liquid through the towels, straining into a two-quart pan or bowl.

Repeat the filtering process using four or more layers of coffee filters. The original instructions did not call for this, however, it has been determined that additional filtrations is needed to remove larger organic compounds that cause the more common, though mild, side effects. See Tips and Advice.

To preserve the product, you can mix the remaining with 80 proof vodka, or apple cider vinegar (organic non-distilled is by far the best), 50/50 as a preservative, extending shelf life by at least 6 months. For flavor, you may choose to add some of your favorite pancake syrup, such as boysenberry, for flavoring, in moderation.

Using a funnel, pour into 20 oz plastic empty water bottles with tight lids, or better still, brown glass bottles, and refrigerate. Avoid direct sunlight on the final liquid, as it will degrade in sunlight.

Dosage:

Because this is an extract that acts like digitalis, which makes your heart work harder, those with heart conditions or high blood pressure should only use oleander soup with medical supervision, preferably someone well versed in integrative medicine.

Begin slowly, with small amounts, increasing slowly as your system adapts. Begin with ¼ to ½ of a teaspoon two or three times a day after meals, work up slowly, a week at a time, until you reach 1 tablespoon three times a day after meals. Side effects are normally fairly mild, especially when compared to standard chemo or radiation therapy side effects, and vary from one individual to another. Some people report little or no side effects at all. Typical side effects for those who do experience them can include mild fever, headache, diarrhea, nausea and sometimes, vomiting. Usually these effects go away in a couple of weeks or so, as the body adjusts to the oleander soup. After a month or so, perhaps much less, you should be up to tolerating the full dose (1 Tablespoon 3 times per day) with minimum reaction. The dosage may vary with individual use, depending upon body weight and sensitivity, and taking a little more is not harmful, but might increase diarrhea.

To counter diarrhea, some oleander soup users take over the counter diarrhea control medicine, like Immodium.

Note: It is the author`s very strong belief that the key to avoiding most, if not all, side effects, is extra filtration. See Tips and Advice (http://www.tbyil.com/tips.htm) .

Duration of Dosage:

Once a cell proliferating disease like cancer is stopped, it can return. Continuation of smaller maintenance dosages should be strongly considered.

Prevention/Maintenance Dosage:

One regular dose three times a week (one Tablespoon) forever. It`s easy to make, costs almost nothing (if you live in the south). It is believed that long term usage boosts the immune system, helps prevent many diseases, targets and kills bad cells and only bad cells, and in some cases, leads to weight loss, more energy, and a lower craving for the dietary "sin foods" like ice-cream and cake.

Learn more: http://www.naturalnews.com/023552_Olean ... z4CnCDCPb8

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 Post subject: Re: Oleander extract
PostPosted: Sun Feb 12, 2017 4:32 pm 
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Therapeutic nerium oleander extract compositions and methods of using

Patent US 8486465 B1

Abstract

The compositions and methods described herein relate generally to therapeutic compositions containing Nerium species extracts, as well as to methods for treating diseases or disorders by administering the compositions, including compositions having a combination of Nerium species extract and glutathione. It further includes pharmaceutical compositions containing a combination of glutathione and a Nerium species extract. The compositions and methods disclosed may be useful for treating a variety of diseases or disorders including one or more cell-proliferative diseases or disorders, infections, and dementias.


METHODS

Preparation of Nerium Oleander Extract.

The production of the Nerium oleander extract is generally similar to the hot water extraction technique disclosed in U.S. Pat. No. 5,135,745. Hot water extraction provides Nerium species extracts which contain a variety of components including without limitation immunologically active polysaccharides. Preferred species of Nerium for preparation of extracts are N. indicuim and N. oleander.

The extracts of the embodiments are preferably prepared from the branches, leaves and flowers of the Nerium oleander plant which can be sliced into pieces preferably ranging in size from about 2 cm to about 2.5 cm in length. Within about 1 week of collecting and slicing the plant material, the sliced plant material is suspended in a polar inorganic solvent, such as water, and heated to about 100° C (212° F). Heating at about 100° C. was continued for about 2.5 hours, during which time loss of liquid due to evaporation is compensated for by the addition of water to the vessel. At the end of the initial heat treatment, the density of the aqueous phase is determined. If the density is less than about 1010 kg/m3 (1.01 gm/cc), the extract is again heated until the desired density is obtained. After the proper density is obtained, the mixture is allowed to cool to room temperature, filtered to remove large particulate matter, filtered again to eliminate small particulate matter, aliquoted into appropriate containers and sealed. After this second filtration, the sealed containers are again heated to about 100° C. for about 1 hour. Following this second heat treatment, the bottles are stored at room temperature for about 10 hours. In this form, the extract has a shelf life of about one year when stored between about 35° F. and 39° F.

Preparation of Nerium Oleander Extract.

The branches, leaves and flowers of Nerium oleander were collected and sliced into pieces from about 2 to about 2.5 cm in length. Within about one week following collection and slicing of the plant material, an extract was prepared from the plant material by adding approximately 2 kg of sliced plant material to about 10 kg of distilled water in an enamel container. This mixture of material was heated until it started boiling, after which time the plant material was boiled for about 2.5 hours. During boiling, distilled water was added to the container to compensate for evaporation, in order to maintain a constant water level in the container. At the end of about 2.5 hours of boiling, the density of the aqueous phase extract was about 1010 kg/m3, as measured using a buoyancy densitometer. If the density was less than about 1010, the extract was boiled for about another half hour until the desired density was attained through further evaporation. After boiling, the mixture was allowed to stand at room temperature for a period of about 6 to about 8 hours. Next, the mixture was processed through a coarse filter in order to remove any large particulate matter such as leaves and branches. The filtrate was then subjected to a second filtration through a medical filter and decanted into 700 ml bottles having tight lids. Within about 4 hours after this last filtration step, the bottles were heated to about 100° C. for about 1 hour. Following this second heat treatment, the bottles were stored at room temperature for about 10 hours. In this form, the extract can have a shelf life of up to about one year when stored at about 2° C. to about 4° C. Filters known and used in the art are suitable for the methods of making the extract and compositions provided herein.

Application

The Nerium species extract can be administered to a subject by any suitable route that ensures bioavailability in the circulation of the subject. This can often best be achieved by parenteral routes of administration including intravenous, intramuscular, intradermal, subcutaneous and intraperitoneal injections. However, other routes of administration can be used. For example, absorption through the gastrointestinal tract can be accomplished by oral routes of administration, including but not limited to, ingestion, buccal and sublingual routes.

In one embodiment, the compositions can be administered transcutaneously (e.g. transdermally or topically) or by inhalation. It will be appreciated that the preferred route can vary with the condition, age and compliance of the subject.

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