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 Post subject: bacteria in tumor cells
PostPosted: Sat Sep 23, 2017 8:45 am 
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Joined: Wed May 27, 2015 10:20 am
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For years and years, the medical establishment has denied that cancer tumors contain bacteria or any microbe for that matter. Now in a recent study, this was found:

Quote:
The team showed that by checking biopsies from the tumors of 113 pancreatic cancer patients, as well as samples from 20 healthy pancreases taken from organ donors. Just 15 percent of the healthy organs contained traces of bacterial DNA, compared to 76 percent of the tumor samples. And while bacterial DNA could just have come from dead cells, the team also saw whole intact bacteria within the tumors.


Now, I an not saying that cancers are induced by microbes all the time as some segments of the alternative medical world would believe, but they may have more to do with cancers than we suspect. In this study, researchers suggest that bacteria are protecting cancer cells. Maybe they are protecting them because they caused them??

Quote:
Debugging a cancer therapy

Microbes contribute not only to the development of human diseases but also to the response of diseases to treatment. Geller et al. show that certain bacteria express enzymes capable of metabolizing the cancer chemotherapeutic drug gemcitabine into an inactive form. When bacteria were introduced into tumors growing in mice, the tumors became resistant to gemcitabine, an effect that was reversed by antibiotic treatment. Interestingly, a high percentage of human pancreatic ductal adenocarcinomas, a tumor type commonly treated with gemcitabine, contain the culprit bacteria. These correlative results raise the tantalizing possibility that the efficacy of an existing therapy for this lethal cancer might be improved by cotreatment with antibiotics.

Science, this issue p. 1156
Abstract

Growing evidence suggests that microbes can influence the efficacy of cancer therapies. By studying colon cancer models, we found that bacteria can metabolize the chemotherapeutic drug gemcitabine (2′,2′-difluorodeoxycytidine) into its inactive form, 2′,2′-difluorodeoxyuridine. Metabolism was dependent on the expression of a long isoform of the bacterial enzyme cytidine deaminase (CDDL), seen primarily in Gammaproteobacteria. In a colon cancer mouse model, gemcitabine resistance was induced by intratumor Gammaproteobacteria, dependent on bacterial CDDL expression, and abrogated by cotreatment with the antibiotic ciprofloxacin. Gemcitabine is commonly used to treat pancreatic ductal adenocarcinoma (PDAC), and we hypothesized that intratumor bacteria might contribute to drug resistance of these tumors. Consistent with this possibility, we found that of the 113 human PDACs that were tested, 86 (76%) were positive for bacteria, mainly Gammaproteobacteria.

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